In the first Indiana Jones film, "Raiders of the Lost Ark", the role of Indy's leading lady, Marion Ravenwood (only the most awesome female character in history of film), was played by Karen Allen. The role was initially offered to Amy Irving, who was dating director Steven Spielberg at the time. The two broke it off, and Allen was cast instead.
In the second Indiana Jones film, "Indiana Jones and the Temple of Doom", the role of Indy's leading lady, Willie Scott (only the most annoying female character in history of film), was played by Kate Capshaw. Spielberg would end up marrying Capshaw, but not before marrying — and divorcing — Amy Irving.
In the third Indiana Jones film, "Indiana Jones and the Last Crusade", the role of Indy's leading lady, Elsa Schneider (only the most treacherous female character in history of film), was played by Alison Doody. Amy Irving didn't figure, except for the fact that the release of the movie coincided with her and Spielberg's heavily-contested, $100 million divorce settlement.
In the fourth Indiana Jones film...
Let's just not discuss the fourth Indiana Jones film, OK?